Transgenic overexpression of Abcb11 enhances biliary bile salt outputs, but does not affect cholesterol cholelithogenesis in mice
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RAGE Does Not Affect Amyloid Pathology in Transgenic ArcA Mice
Background: Alzheimer’s disease (AD) is characterized by brain accumulation of the amyloidpeptide (A ) that triggers a cascade of biochemical and cellular alterations resulting in the clinical phenotype of the disease. While numerous experiments addressed A toxicity, the mechanisms are still not fully understood. The receptor for advanced glycation end products (RAGE) binds A and was suggested ...
متن کاملHepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.
The bile salt export pump, encoded by ABCB11, is the predominant canalicular transport protein for biliary bile acid secretion. The level of ABCB11 expression in humans is widely variable yet the impact of this variability on human disease is not well defined. We aim to determine the effect of hepatic Abcb11 overexpression on the enterohepatic circulation (EHC) in mice. We used a stable isotope...
متن کاملABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice.
The discovery of the ABCA1 lipid transporter has generated interest in modulating human plasma HDL levels and atherogenic risk by enhancing ABCA1 gene expression. To determine if increased ABCA1 expression modulates HDL metabolism in vivo, we generated transgenic mice that overexpress human ABCA1 (hABCA1-Tg). Hepatic and macrophage expression of hABCA1 enhanced macrophage cholesterol efflux to ...
متن کاملActivity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.
Mutations in ATP8B1 cause severe inherited liver disease. The disease is characterized by impaired biliary bile salt excretion (cholestasis), but the mechanism whereby impaired ATP8B1 function results in cholestasis is poorly understood. ATP8B1 is a type 4 P-type ATPase and is a flippase for phosphatidylserine. Atp8b1-deficient mice display a dramatic increase in the biliary extraction of chole...
متن کاملOverexpression of human apolipoprotein A-II in transgenic mice does not impair macrophage-specific reverse cholesterol transport in vivo.
BACKGROUND Overexpression of human apolipoprotein (apo) A-II in transgenic mice induces high-density lipoprotein (HDL) deficiency, and increased atherosclerosis susceptibility only when fed an atherogenic diet. This may, in part, be caused by impairment in reverse cholesterol transport (RCT). METHODS AND RESULTS [3H]cholesterol-labeled macrophages were injected intraperitoneally into mice mai...
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ژورنال
عنوان ژورنال: European Journal of Clinical Investigation
سال: 2010
ISSN: 0014-2972,1365-2362
DOI: 10.1111/j.1365-2362.2010.02300.x